Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.

ABSTRACT: The hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity. In coronavirus disease 2019 (COVID-19), dysregulation of the hemostatic and complement systems has been associated with several complications. To understand the essential balance between activation and regulation of these systems, a quantitative systems immunology model can be established. The dynamics of the components are examined under three distinct conditions: the disease state representing symptomatic COVID-19 state, an intervened disease state marked by reduced levels of regulators, and drug interventions including heparin, tranexamic acid, avdoralimab, garadacimab, and tocilizumab. Simulation results hi

SUBMITTER: Murad D 

PROVIDER: S-EPMC11781117 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature