DDX17-Mediated Upregulation of CXCL8 Promotes Hepatocellular Carcinoma Progression <i>via</i> Co-activating β-catenin/NF-κB Complex.

ABSTRACT: Hepatocellular carcinoma (HCC) is a well-known inflammation-related cancer, that accounts for fifth most prevalent neoplasm and the third major driver of cancer associated fatality globally. Accumulating evidence has elucidated that C-X-C motif chemokine ligands (CXCLs) are aberrantly upregulated in HCC and are involved in inflammation-induced hepatocarcinogenesis and metastasis. Herein, we identified a novel function of DEAD-box RNA helicase 17 (DDX17) as an oncogenic factor via transactivating CXCL8 in HCC. Unlike the adjacent nontumor tissues, DDX17 was highly expressed in tumor tissues compared in two independent cohorts and that it acts as an independent prognostic indicator for patients who have HCC. Mechanistically, DDX17 interacts with β-catenin and NF-κB, and promotes their nuclea

SUBMITTER: Liu H 

PROVIDER: S-EPMC11781183 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature