Development of a yeast-based sensor platform for evaluation of ligands recognized by the human free fatty acid 2 receptor.

ABSTRACT: Yeast-based sensors have shown great applicability for deorphanization of G protein-coupled receptors (GPCRs) and screening of ligands targeting these. A GPCR of great interest is free fatty acid 2 receptor (FFA2R), for which short-chain fatty acids such as propionate and acetate are agonists. FFA2R regulates a wide array of downstream receptor signaling pathways in both adipose tissue and immune cells and has been recognized as a promising therapeutic target, having been implicated in several metabolic and inflammatory diseases. While research aiming to identify ligands recognized by FFA2R for translational applications is ongoing, screening is complicated by the complex regulatory and cell-specific responses mediated by the receptor. To simplify screening towards identification of novel

SUBMITTER: Clausen Lind A 

PROVIDER: S-EPMC11781196 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature