Protective role of triiodothyronine in sepsis‑induced cardiomyopathy through phospholamban downregulation.

ABSTRACT: Sepsis is often a cause of mortality in patients admitted to the intensive care unit. Notably, the heart is the organ most susceptible to the impact of sepsis and this condition is referred to as sepsis‑induced cardiomyopathy (SIC). Low triiodothyronine (T3) syndrome frequently occurs in patients with sepsis, and the heart is one of the most important target organs for the action of T3. Phospholamban (PLN) is a key protein associated with Ca²⁺‑pump‑mediated cardiac diastolic function in the myocardium of mice with SIC, and PLN is negatively regulated by T3. The present study aimed to explore whether T3 can protect cardiac function during sepsis and to investigate the specific molecular mechanism underlying the regulation of PLN by T3. C57BL/6J mice and H9C2 cells were used to es

SUBMITTER: Xie Q 

PROVIDER: S-EPMC11781518 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature