Systematic review and network meta-analysis of agomelatine for the treatment of generalized anxiety disorder in adult patients.

ABSTRACT: This systematic literature review aimed to assess the efficacy and tolerability of agomelatine versus approved medications for the treatment of generalized anxiety disorder (GAD) in adult patients. We selected randomized controlled trials on various medications used to treat GAD in adult patients. An existing systematic literature review ( Kong et al ., 2020 ) was used to identify relevant studies published before 2020. Outcomes of remission and discontinuation due to adverse events (AEs) were analyzed, following a random-effects network meta-analysis approach. Of 25 identified studies, 20 and 22 studies were included in the network meta-analysis for studying the remission and discontinuation (due to AEs) outcomes, respectively. A statistically significant difference in the remission rate

SUBMITTER: Hood SD 

PROVIDER: S-EPMC11781552 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature