The emerging role of growth differentiation factor 15 as a potential disease biomarker in juvenile dermatomyositis.

ABSTRACT:

Objective

We aimed to investigate the potential of growth differentiation factor 15 (GDF-15) as a novel biomarker for disease activity in JDM.

Methods

We recruited children with juvenile myositis including JDM (n = 77), PM (n = 6) and healthy controls (n = 22). GDF-15 levels in plasma were measured using ELISA. Statistical analyses were performed using non-parametric tests.

Results

Levels of GDF-15 were significantly elevated in JDM compared with healthy controls (P < 0.001). GDF-15 levels exhibited strong positive correlations with DASs, including the DAS total score, DAS skin score, DAS muscle score and Childhood Myositis Assessment Scale. Additionally, GDF-15 levels could differentiate between active disease and remission based on the Physician Global Assessment of

SUBMITTER: Duvvuri B 

PROVIDER: S-EPMC11781582 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature