Predictors of lack of response to methotrexate in juvenile idiopathic arthritis associated uveitis.

ABSTRACT:

Objectives

To investigate clinical features associated with lack of response to MTX in juvenile idiopathic arthritis associated uveitis (JIA-U).

Methods

Clinical records of JIA-U patients were retrospectively reviewed. Differences among variables were assessed by Mann-Whitney and χ2 or Fisher's exact tests as appropriate. Association between predictors and requirement of a biological disease-modifying antirheumatic drug (bDMARD) was evaluated by univariate Cox regression analysis and Kaplan-Meier curves. A multivariable logistic model was applied to estimate strength of association, adjusting for potential confounders.

Results

Data from 99 JIA-U patients treated with MTX were analysed (82.8% female), with a mean follow up of 9.2 years and a mean age at uveitis onset o

SUBMITTER: Mapelli C 

PROVIDER: S-EPMC11781584 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature