Associations between plasma metabolism-associated proteins and future development of giant cell arteritis: results from a prospective study.

ABSTRACT:

Objective

The aim of this study was to investigate the relationship between biomarkers associated with metabolism and subsequent development of GCA.

Method

Participants in the population-based Malmö Diet Cancer Study (MDCS; N = 30 447) who were subsequently diagnosed with GCA were identified in a structured process. Matched GCA-free controls were selected from the study cohort. Baseline plasma samples were analysed using the antibody-based OLINK proteomics metabolism panel (92 metabolic proteins). Analyses were pre-designated as hypothesis-driven or hypothesis-generating. In the latter, principal component analysis was used to identify groups of proteins that explained the variance in the proteome.

Results

There were 95 cases with a confirmed incident diagnosis of GCA

SUBMITTER: Wadstrom K 

PROVIDER: S-EPMC11781587 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature