The Japanese encephalitis virus NS1' protein facilitates virus infection in mosquitoes.

ABSTRACT:

Background

The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is known for its capacity to cause severe neurological disease in Asia. Neurotropic flaviviruses within the Japanese encephalitis (JE) serogroup possess the distinctive feature of expressing a unique nonstructural protein, NS1'. The NS1' protein consists of the full NS1 protein with an additional 52 amino acid extension at the C-terminus and has been demonstrated to exhibit virulence in mammalian hosts upon infection. However, the precise role of the NS1' protein in the mosquito vectors has yet to be elucidated.

Methodology/principal findings

In this study, an NS1'-defective virus (rG66A) was engineered, and its effect on the infection of mosquito cells was investigated. The results demonstrated a

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11781682 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature