Net buffer load during regional citrate anticoagulated continuous renal replacement therapy.

ABSTRACT:

Background

Regionally anticoagulated continuous renal replacement therapy with citrate is the first choice for critically ill patients with acute kidney injury. If citrate that reaches the patient exceeds the metabolic capacity, metabolic alkalosis will follow. Bicarbonate from the treatment fluids will also reach the patient and add to the bicarbonate load. Net buffer load is a parameter calculated by the dialysis machine software from the treatment fluid contents, the fluid flows and the filter properties. Each time the treatment settings are altered the net buffer load will be re-calculated. This parameter is integrated as a static safety parameter in the Prismax version 3 software, and will guide the operator on a possible development of metabolic alkalosis with the current set

SUBMITTER: Forsal I 

PROVIDER: S-EPMC11781738 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature