Insights into the origin, hybridisation and adaptation of Candida metapsilosis hybrid pathogens.

ABSTRACT: Hybridisation is a source of genetic diversity, can drive adaptation to new niches and has been found to be a frequent event in lineages harbouring pathogenic fungi. However, little is known about the genomic implications of hybridisation nor its impact on pathogenicity-related traits. A common limitation for addressing these questions is the narrow representativity of sequenced genomes, mostly corresponding to strains isolated from infected patients. The opportunistic human pathogen Candida metapsilosis is a hybrid that descends from the crossing between unknown parental lineages. Here, we sequenced the genomes of five new C. metapsilosis isolates, one representing the first African isolate for this species, and four environmental isolates from marine niches. Our comparative genomic analy

SUBMITTER: Del Olmo V 

PROVIDER: S-EPMC11781744 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature