Identification of cuproptosis and ferroptosis-related subtypes and development of a prognostic signature in colon cancer.

ABSTRACT: Colon cancer, as a highly prevalent malignant tumor globally, poses a significant threat to human health. In recent years, ferroptosis and cuproptosis, as two novel forms of cell death, have attracted widespread attention for their potential roles in the development and treatment of colon cancer. However, the investigation into the subtypes and their impact on the survival of colon cancer patients remains understudied. In this study, utilizing data from TCGA and GEO databases, we examined the expression differences of ferroptosis and cuproptosis-related genes in colon cancer and identified two subtypes. Through functional analysis and bioinformatics methods, we elucidated pathway differences and biological characteristics between these two subtypes. By leveraging differential genes between

SUBMITTER: He Y 

PROVIDER: S-EPMC11781745 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature