Longer recreational screen time contributes to the risk of age-related macular degeneration: a UK Biobank cohort study and two-sample Mendelian randomisation.

ABSTRACT:

Background

Recreational screen time (RST) has been found to be associated with cognitive decline and neurodegenerative diseases. However, the association between RST and age-related macular degeneration (AMD), an ocular neurodegenerative disease, is still unclear. We aimed to elucidate the association between RST and AMD.

Methods

This study consisted of three parts: 1) a prospective cohort study with 482 939 UK Biobank participants and a 12.8-year median follow-up to explore the association between RST and incident AMD; 2) a two-sample Mendelian randomisation (MR) analysis using summary-level genome-wide association analysis data for RST based on 526 725 European individuals to assess causality between RST and AMD; and 3) a cross-sectional study involving 38 478 UK Biobank i

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11781809 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature