Lack of context modulation in human single neuron responses in the medial temporal lobe.

ABSTRACT: In subjects implanted with intracranial electrodes, we use two different stories involving the same person (or place) to evaluate whether and to what extent context modulates human single-neuron responses. Nearly all neurons (97% during encoding and 100% during recall) initially responding to a person/place do not modulate their response with context. Likewise, nearly none (<1%) of the initially non-responsive neurons show conjunctive coding, responding to particular persons/places in a particular context during the tasks. In line with these findings, taking all neurons together it is possible to decode the person/place being depicted in each story, but not the particular story. Moreover, the neurons show consistent results across encoding and recall of the stories and during passive viewi

SUBMITTER: Rey HG 

PROVIDER: S-EPMC11781864 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature