Microglial cell proliferation is regulated, in part, by reactive astrocyte ETB_R signaling after ischemic stroke.

ABSTRACT: Reciprocal communication between reactive astrocytes and microglial cells provides local, coordinated control over critical processes such as neuroinflammation, neuroprotection, and scar formation after CNS injury, but is poorly understood. The vasoactive peptide hormone endothelin (ET) is released and/or secreted by endothelial cells, microglial cells and astrocytes early after ischemic stroke and other forms of brain injury. To better understand glial cell communication after stroke, we sought to identify paracrine effectors produced and secreted downstream of astroglial endothelin receptor B (ETB_R) signaling. Using a genetic loss-of-function screen, we identified angiopoietin-2 (Ang-2) as a factor produced by reactive astrocytes in response to ET. In experiments with primary

SUBMITTER: McInnis JJ 

PROVIDER: S-EPMC11781953 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature