Development of a refined harmonization approach for longitudinal cognitive data in people with HIV.

ABSTRACT:

Objectives

The aim of this study was to develop a refined method for harmonizing longitudinal cognitive data across several large-scale studies in people with HIV (PWH), in whom cognitive complications are common and heterogeneous in presentation.

Study design and setting

We developed a refined method for harmonizing longitudinal cognitive data across five large-scale studies in PWH that used different cognitive batteries with only some overlapping tests-Women's Interagency HIV Study (WIHS), Multicenter AIDS Cohort Study, CNS HIV Antiretroviral Therapy Effects Research (CHARTER), National NeuroAIDS Tissue Consortium, and the HIV Neurobehavioral Research Program. Traditional data harmonization methods using latent variable models focus on cross-sectional data and require the

SUBMITTER: Lang L 

PROVIDER: S-EPMC11781957 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature