X-Chromosome-Linked miRNAs Regulate Sex Differences in Cardiac Physiology.

ABSTRACT:

Background

Males and females exhibit distinct anatomic and functional characteristics of the heart, predisposing them to specific disease states.

Methods

We identified microRNAs (miRNAs/miR) with sex-differential expression in mouse hearts.

Results

Four conserved miRNAs are present in a single locus on the X-chromosome and are expressed at higher levels in females than males. We show miRNA, miR-871, is responsible for decreased expression of the protein SRL (sarcalumenin) in females. SRL is involved in calcium signaling, and we show it contributes to differences in electrophysiology between males and females. miR-871 overexpression mimics the effects of the cardiac physiology of conditional cardiomyocyte-specific Srl-null mice. Inhibiting miR-871 with an antagomir in

SUBMITTER: Emerson JI 

PROVIDER: S-EPMC11781965 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature