Biomarkers to Predict Abnormal Technetium-99m Pyrophosphate Scans in Patients With Suspected Transthyretin Amyloidosis.

ABSTRACT:

Background

Technetium Tc 99m pyrophosphate scintigraphy (^99mTc PYP imaging) is a diagnostic tool for transthyretin amyloid cardiomyopathy (ATTR-CM). Cardiac biomarkers, particularly high-sensitivity cardiac troponin (hs-cTn) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), may help identify patients at low or high risk for ATTR-CM.

Objectives

The authors sought to evaluate the predictive value of hs-cTnT and NT-proBNP in patients undergoing ^99mTc PYP imaging for suspected ATTR-CM in a large U.S. cohort.

Methods

This was a retrospective study of patients who underwent ^99mTc PYP imaging between May 2013 and September 2022, including those with at least 1 hs-cTnT measurement within 6 months of the scan.

Results

ATTR-CM wa

SUBMITTER: De Michieli L 

PROVIDER: S-EPMC11781999 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature