Serum Proteins Predict Treatment-Related Cardiomyopathy Among Survivors of Childhood Cancer.

ABSTRACT:

Background

Anthracyclines, a highly effective chemotherapy for many pediatric malignancies, cause cardiomyopathy, a major late effect in adult survivors. Biomarkers are needed for early detection and targeted interventions for anthracycline-associated cardiomyopathy.

Objectives

The aim of this study was to determine if serum proteins and/or metabolites in asymptomatic childhood cancer survivors can discriminate symptomatic cardiomyopathy.

Methods

Using an untargeted mass spectrometry-based approach, 867 proteins and 218 metabolites were profiled in serum samples of 75 asymptomatic survivors with subclinical cardiomyopathy and 75 individually matched survivors without cardiomyopathy from SJLIFE (St. Jude Lifetime Cohort Study). Models were developed on the basis of the

SUBMITTER: Poudel S 

PROVIDER: S-EPMC11782007 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature