Causal relationship between 412 gut microbiota, 1,400 blood metabolites, and diabetic nephropathy: a randomized Mendelian study.

ABSTRACT:

Objective

The aim of this study was to investigate the causal relationship between microbiota, diabetic nephropathy, and blood metabolites through a randomized Mendelian study.

Methods

In this study, we used 412 microbiota as exposures, 1,400 blood metabolites as intermediaries, and diabetic nephropathy as the outcome. We conducted a two-way Mendelian randomization (MR) analysis to explore the causal relationship between microbiota and diabetic nephropathy, followed by mediation analyses and two-step MR to identify potential blood metabolites.

Results

There is a causal relationship between microbiota and diabetic nephropathy. Specific bacteria and metabolites, such as Escherichia coli str. K-12 substr. MG1655, Listeria monocytogenes 10403S, g_Adlercre

SUBMITTER: Cao BN 

PROVIDER: S-EPMC11782027 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature