Addressing immortal time bias in precision medicine: Practical guidance and methods development.

ABSTRACT:

Objective

To compare theoretical strengths and limitations of common immortal time adjustment methods, propose a new approach using multiple imputation (MI), and provide practical guidance for using MI in precision medicine evaluations centered on a real-world case study.

Study setting and design

Methods comparison, guidance, and real-world case study based on previous literature. We compared landmark analysis, time-distribution matching, time-dependent analysis, and our proposed MI application. Guidance for MI spanned (1) selecting the imputation method; (2) specifying and applying the imputation model; and (3) conducting comparative analysis and pooling estimates. Our case study used a matched cohort design to evaluate overall survival benefits of whole-genome and transcri

SUBMITTER: Weymann D 

PROVIDER: S-EPMC11782076 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature