Concomitant Administration of Dantrolene is Sufficient to Protect Against Doxorubicin-Induced Cardiomyopathy.

ABSTRACT:

Background

Doxorubicin (DOX), a commonly used anticancer agent, can result in cardiac dysfunction, presenting a significant clinical challenge. DOX has been shown to induces Ca²⁺ leakage via the ryanodine receptor 2 (RYR2) of the sarcoplasmic reticulum, increasing Ca²⁺ levels in the cytoplasm.

Objectives

This study investigated whether stabilizing RYR2 could suppress DOX-induced cardiomyopathy (DIC) and identified the optimal duration of dantrolene treatment as a pharmacological method.

Methods

We investigated the effects of RYR2 stabilization on DOX cardiotoxicity using in vivo and in vitro experiments.

Results

DOX administration caused calmodulin dissociation, marked Ca²⁺ leakage from RYR2, and increased oxidative stress in is

SUBMITTER: Nakamura Y 

PROVIDER: S-EPMC11782101 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature