Examination of MGMT as a risk gene for dementia in the Amish.

ABSTRACT:

Introduction

Recently, the O-6-methylguanine-DNA methyltransferase (MGMT) locus was proposed as influencing the risk of Alzheimer's disease (AD) in women who did not carry the apolipoprotein E ε4 allele. We examined an Amish founder population for any influence of genetic variation in and around the MGMT locus on the risk for dementia.

Methods

Genetic association was performed for single nucleotide polymorphisms (SNPs) surrounding the MGMT locus. A total of 946 individuals of Amish descent between the ages of 76 and 95 who were classified as cognitively impaired or cognitively unimpaired were included. Multiple statistical models were applied to test for replication.

Results

The results for the previously associated individual SNPs were not significant. However, a dif

SUBMITTER: Main LR 

PROVIDER: S-EPMC11782184 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature