Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration.

ABSTRACT:

Objective

The aim of this study was to establish a pharmacodynamic model of tapentadol analgesia under dose titration conditions, to quantitatively analyze the time-effect relationship of the drug, and to identify relevant influencing factors. This model is intended to provide a pharmacodynamic reference for designing rational tapentadol dose titration schemes in clinical research.

Methods

Randomized controlled trials assessing the efficacy of tapentadol in the management of chronic pain were retrieved from public databases (PubMed and EMBASE). A time-effect relationship model of the percent change in Numerical Rating Scale (NRS) scores post-tapentadol intervention from baseline was constructed, along with a covariate model to identify factors significantly impacting the ana

SUBMITTER: Xin L 

PROVIDER: S-EPMC11782195 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature