Major and minor perineural invasion in salivary gland cancer.

ABSTRACT:

Objective

To delineate the distribution of perineural invasion (PNI), evaluate its impact on patient survival, and identify optimal criteria for initiating adjuvant radiation therapy (RT) in cases of PNI associated with salivary gland cancer (SGC).

Methods

This retrospective study categorized enrolled patients into three groups based on PNI status (none, minor, or major), defined by the extent of nerve involvement. The influence of PNI on overall survival and locoregional control was assessed using a Cox proportional hazards model.

Results

A total of 555 patients were incorporated into the study. Logistic regression analysis indicated that tumor stage, neck stage, histological grade, and pathological type were independently linked to the occurrence of PNI. In the Cox

SUBMITTER: Liu F 

PROVIDER: S-EPMC11782203 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature