The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome.

ABSTRACT:

Introduction

Development of Alzheimer's disease (AD) pathology in Down's syndrome (DS) occurs within a compressed timeline compared to sporadic or other genetic forms of AD.

Methods

Plasma glial fibrillary acidic protein (GFAP) and plasma pTau-217 levels were compared by AD pathophysiology (amyloid (A+) and tau (T+) positron emission tomography [PET]) in persons with DS (N = 348) and sibling controls (N = 42). Plasma GFAP, plasma pTau-217, amyloid-PET, and tau-PET levels were compared with regard to estimated years to onset of clinical symptoms (52.5 years old). We evaluated if plasma GFAP mediated the relationship between amyloid PET and plasma pTau-217 or tau PET.

Results

Plasma GFAP, a measure of astrogliosis, was elevated in A+/T- and A+/T+ individuals with DS. Pl

SUBMITTER: Boerwinkle AH 

PROVIDER: S-EPMC11782213 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature