A machine learning-based radiomics approach for differentiating patellofemoral osteoarthritis from non-patellofemoral osteoarthritis using Q-Dixon MRI.

ABSTRACT: This prospective diagnostic study aimed to assess the utility of machine learning-based quadriceps fat pad (QFP) radiomics in distinguishing patellofemoral osteoarthritis (PFOA) from non-PFOA using Q-Dixon MRI in patients presenting with anterior knee pain. This diagnostic accuracy study retrospectively analyzed data from 215 patients (mean age: 54.2 ± 11.3 years; 113 women). Three predictive models were evaluated: a proton density-weighted image model, a fat fraction model, and a merged model. Feature selection was conducted using analysis of variance, and logistic regression was applied for classification. Data were collected from training, internal, and external test cohorts. Radiomics features were extracted from Q-Dixon MRI sequences to distinguish PFOA from non-PFOA. The diagnostic p

SUBMITTER: Lyu L 

PROVIDER: S-EPMC11782249 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature