Performance of amide proton transfer imaging to differentiate true progression from therapy-related changes in gliomas and metastases.

ABSTRACT:

Objectives

Differentiating true progression or recurrence (TP/TR) from therapy-related changes (TRC) is complex in brain tumours. Amide proton transfer-weighted (APT) imaging is a chemical exchange saturation transfer (CEST) MRI technique that may improve diagnostic accuracy during radiological follow-up. This systematic review and meta-analysis elucidated the level of evidence and details of state-of-the-art imaging for APT-CEST in glioma and brain metastasis surveillance.

Methods

PubMed, EMBASE, Web of Science, and Cochrane Library were systematically searched for original articles about glioma and metastasis patients who received APT-CEST imaging for suspected TP/TR within 2 years after (chemo)radiotherapy completion. Modified Quality Assessment of Diagnostic Accuracy Stu

SUBMITTER: Essed RA 

PROVIDER: S-EPMC11782315 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature