In vivo assessment of the nephrotoxic effects of the synthetic cannabinoid AB-FUBINACA.

ABSTRACT:

Background

The widespread misuse of synthetic cannabinoids (SCs) has led to a notable increase in reported adverse effects, raising significant health concerns. SCs use has been particularly associated with acute kidney injury (AKI). However, the pathogenesis of SCs-induced AKI is not well-understood.

Methods

We investigated the nephrotoxic effect of acute administration of N-[(1S)- 1-(aminocarbonyl)-2-methylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide (AB-FUBINKA) (3 mg/kg for 5 days) in mice. Various parameters of oxidative stress, inflammation, and apoptosis have been quantified. The expressions of mitochondrial complexes (I-V) in renal tissues were also assessed.

Results

Our findings showed that AB-FUBINACA induced substantial impairment in the ren

SUBMITTER: Alzu'bi A 

PROVIDER: S-EPMC11782324 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature