Calibration of Aseptic Loosening Simulation for Coatings Osteoinductive Effect.

ABSTRACT: The risk of aseptic loosening in cementless hip stems can be reduced by improving osseointegration with osteoinductive coatings favoring long-term implant stability. Osseointegration is usually evaluated in vivo studies, which, however, do not reproduce the mechanically driven adaptation process. This study aims to develop an in silico model to predict implant osseointegration and the effect of induced micromotion on long-term stability, including a calibration of the material osteoinductivity with conventional in vivo studies. A Finite Element model of the tibia implanted with pins was generated, exploiting bone-to-implant contact measures of cylindrical titanium alloys implanted in rabbits' tibiae. The evolution of the contact status between bone and implant was modeled using a finite st

SUBMITTER: Baroni S 

PROVIDER: S-EPMC11782331 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature