Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized ¹²⁹Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers.

ABSTRACT:

Objectives

3D phase-resolved functional lung (PREFUL) MRI offers evaluation of pulmonary ventilation without inhalation of contrast agent. This study seeks to compare ventilation maps obtained from 3D PREFUL MRI with a direct ventilation measurement derived from ¹²⁹Xe MRI in both patients with chronic obstructive pulmonary disease (COPD) and healthy volunteers.

Methods

Thirty-one patients with COPD and 12 healthy controls underwent free-breathing 3D PREFUL MRI and breath-hold ¹²⁹Xe MRI at 1.5 T. For both MRI techniques, ventilation defect (VD) maps were determined and respective ventilation defect percentage (VDP) values were computed. All parameters of both techniques were compared by Spearman correlation coefficient (r) and the differences between VDP

SUBMITTER: Klimes F 

PROVIDER: S-EPMC11782336 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature