Measuring repeatability of dynamic contrast-enhanced MRI biomarkers improves evaluation of biological response to radiotherapy in lung cancer.

ABSTRACT:

Objectives

To measure dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) biomarker repeatability in patients with non-small cell lung cancer (NSCLC). To use these statistics to identify which individual target lesions show early biological response.

Materials and methods

A single-centre, prospective DCE-MRI study was performed between September 2015 and April 2017. Patients with NSCLC were scanned before standard-of-care radiotherapy to evaluate biomarker repeatability and two weeks into therapy to evaluate biological response. Volume transfer constant (K^trans), extravascular extracellular space volume fraction (v_e) and plasma volume fraction (v_p) were measured at each timepoint along with tumour volume. Repeatability was assessed

SUBMITTER: Sridharan N 

PROVIDER: S-EPMC11782379 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature