GlyCompute: towards the automated analysis of protein N-linked glycosylation kinetics via an open-source computational framework.

ABSTRACT: Understanding the complex biosynthetic pathways of glycosylation is crucial for the expanding field of glycosciences. Computer-aided glycosylation analysis has greatly benefited in recent years from the development of tools found in web-based portals and open-source libraries. However, the in silico analysis of cellular glycosylation kinetics is underrepresented in current glycoscience-related tools and databases. This could be partly attributed to the limited accessibility of kinetic models developed using proprietary software and the difficulty in reliably parameterising such models. This work aims to address these challenges by proposing GlyCompute, an open-source framework demonstrating a novel, streamlined approach for the assembly, simulation, and parameterisation of kinetic models o

SUBMITTER: Flevaris K 

PROVIDER: S-EPMC11782420 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature