An applied noise model for scintillation-based CCD detectors in transmission electron microscopy.

ABSTRACT: Measurements in general are limited in accuracy by the presence of noise. This also holds true for highly sophisticated scintillation-based CCD cameras, as they are used in medical applications, astronomy or transmission electron microscopy. Further, signals measured with pixelated detectors are convolved with the inherent detector point spread function. The Poisson noise, arising from the quantized nature of the beam electrons, gets correlated by this convolution, which allows to reconstruct the detector PSF based on the Wiener-Khinchin theorem and the Pearson correlation coefficients under homogeneous illumination conditions. However, correlation also has a strong impact on the noise statistics of basic operations like the binning of signals, as it is usually done in electron energy-loss

SUBMITTER: Zietlow C 

PROVIDER: S-EPMC11782531 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature