Variable power functional dilution adjustment of spot urine.

ABSTRACT: Spot-urinary biomarkers are crucial in medical, epidemiological, and environmental studies, but their variability due to hydration levels requires precise dilution adjustments. Traditional methods, like conventional creatinine correction (CCRC), are limited in compensating for variations in urine concentration, causing substantial inconsistencies, particularly at the extremes of the diuresis spectrum. While restricting the creatinine (CRN) range to 0.3-3 g/L is recommended to ensure result stability, this approach excludes a substantial proportion of samples and permits notable fluctuations within the accepted range. This study introduces a novel variable power functional creatinine correction method (V-PFCRC) to normalize analytes to 1 g/L CRN by utilizing uncorrected analyte levels and t

SUBMITTER: Carmine TC 

PROVIDER: S-EPMC11782553 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature