Stress landscape of folding brain serves as a map for axonal pathfinding.

ABSTRACT: Understanding the mechanics linking cortical folding and brain connectivity is crucial for both healthy and abnormal brain development. Despite the importance of this relationship, existing models fail to explain how growing axon bundles navigate the stress field within a folding brain or how this bidirectional and dynamic interaction shapes the resulting surface morphologies and connectivity patterns. Here, we propose the concept of "axon reorientation" and formulate a mechanical model to uncover the dynamic multiscale mechanics of the linkages between cortical folding and connectivity development. Simulations incorporating axon bundle reorientation and stress-induced growth reveal potential mechanical mechanisms that lead to higher axon bundle density in gyri (ridges) compared to sulci (

SUBMITTER: Solhtalab A 

PROVIDER: S-EPMC11782574 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature