Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1.

ABSTRACT: Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available. This study investigated the potential repurposing of domperidone, an antiemetic and gastrokinetic agent, to control DENV infection. Domperidone was identified by pharmacophore-based virtual screening as a small molecule that can bind to both the viral envelope (E) and the nonstructural protein 1 (NS1) of DENV. Molecular dynamics (MD) simulations and surface plasmon resonance (SPR) analysis were subsequently performed to determine specific interactions of domperidone with the DENV E and NS1 proteins and their binding affinity. Treatment of immortalized human hepatocyte-like cells (imHC) with d

SUBMITTER: Kaewjiw N 

PROVIDER: S-EPMC11782576 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature