Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

There is no licensed vaccine against gonorrhea, but Neisseria meningitidis serogroup B outer membrane vesicle-based vaccines, such as MenB-4C, may offer cross-protection against gonorrhea. This systematic review and meta-analysis synthesized the published literature on MenB-4C vaccine effectiveness against gonorrhea.

Methods

We conducted a literature search of electronic databases (PubMed, Medline, Embase, Global Health, Scopus, Google Scholar, CINAHL, and Cochrane Library) to identify peer-reviewed articles published in English from 1 January 2013 to 11 September 2024 that reported MenB-4C vaccine effectiveness estimates against gonorrhea and gonorrhea/chlamydia coinfection and the duration of MenB-4C vaccine-induced protection. We estimated pooled MenB-4C vaccin

SUBMITTER: Abara WE 

PROVIDER: S-EPMC11782638 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature