Alzheimer's disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function.

ABSTRACT: The prevalence of Alzheimer's disease (AD) is increasing as society ages. The details of AD pathogenesis have not been fully elucidated, and a comprehensive gene expression analysis of the process leading up to the onset of AD would be helpful for understanding the mechanism. We performed an RNA sequencing analysis on a cohort of 1227 Japanese blood samples, representing 424 AD patients, 543 individuals with mild cognitive impairment (MCI), and 260 cognitively normal (CN) individuals. A total of 883 and 1169 statistically significant differentially expressed genes (DEGs) were identified between CN and MCI (CN-MCI) and between MCI and AD (MCI-AD), respectively. Pathway analyses using these DEGs, followed by protein-protein interaction network analysis, revealed key roles of ribosomal functi

SUBMITTER: Yamakawa A 

PROVIDER: S-EPMC11782650 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature