Exploring the need for a preload on the estimation of permeability, vessel radius, and relative cerebral blood volume in MR vascular fingerprinting-based dynamic susceptibility contrast perfusion imaging.

ABSTRACT:

Purpose

Dynamic susceptibility contrast (DSC) MRI is commonly part of the clinical brain tumor imaging protocol. Usually, a preload of contrast agent is administered to minimize contrast-leakage T₁ effects. However, recent studies have indicated that with adaptation of scan parameters (in particular, low flip angle), a preload is not required. For advanced approaches, like MR vascular fingerprinting (MRVF), which is based on combining gradient-echo and spin-echo readouts, excitation flip angles cannot easily be reduced, but postprocessing might alleviate leakage effects. In this study, the aim was to verify whether DSC-MRVF can be performed without preload.

Methods

A previously established simulation model was used to create a dictionary of DSC-MRVF signals result

SUBMITTER: van Dorth D 

PROVIDER: S-EPMC11782708 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature