Evaluation of an integrated variable flip angle protocol to estimate coil B₁ for hyperpolarized MRI.

ABSTRACT:

Purpose

The purpose of this work is to validate a simple and versatile integrated variable flip angle (VFA) method for mapping B₁ in hyperpolarized MRI, which can be used to correct signal variations due to coil inhomogeneity.

Theory and methods

Simulations were run to assess performance of the VFA B₁ mapping method compared to the currently used constant flip angle (CFA) approach. Simulation results were used to inform the design of VFA sequences, validated in four volunteers for hyperpolarized xenon-129 imaging of the lungs and another four volunteers for hyperpolarized carbon-13 imaging of the human brain. B₁ maps obtained were used to correct transmit and receive inhomogeneity in the images.

Results

Simulations showed improved perf

SUBMITTER: Yeung K 

PROVIDER: S-EPMC11782732 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature