The effects of maternal flow on placental diffusion-weighted MRI and intravoxel incoherent motion parameters.

ABSTRACT:

Purpose

To investigate and explain observed features of the placental DWI signal in healthy and compromised pregnancies using a mathematical model of maternal blood flow.

Methods

Thirteen healthy and nine compromised third trimester pregnancies underwent pulse gradient spin echo DWI MRI, with the results compared to MRI data simulated from a 2D mathematical model of maternal blood flow through the placenta. Both sets of data were fitted to an intravoxel incoherent motion (IVIM) model, and a rebound model (defined within text), which described voxels that did not decay monotonically. Both the in vivo and simulated placentas were split into regions of interest (ROIs) to analyze how the signal varies and how IVIM and rebounding parameters change across the placental width.

R

SUBMITTER: Hutchinson GJ 

PROVIDER: S-EPMC11782734 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature