MVP-VSASL: measuring MicroVascular Pulsatility using velocity-selective arterial spin labeling.

ABSTRACT:

Purpose

By leveraging the small-vessel specificity of velocity-selective arterial spin labeling (VSASL), we present a novel technique for measuring cerebral MicroVascular Pulsatility named MVP-VSASL.

Theory and methods

We present a theoretical model relating the pulsatile, cerebral blood flow-driven VSASL signal to the microvascular pulsatility index ( PI$$ \mathrm{PI} $$ ), a widely used metric for quantifying cardiac-dependent fluctuations. The model describes the dependence of the PI$$ \mathrm{PI} $$ of VSASL signal (denoted PIVS$$ {\mathrm{PI}}_{\mathrm{VS}} $$ ) on bolus duration τ$$ \tau $$ (an adjustable VSASL sequence parameter) and provides guidance for selecting a value of τ$$ \tau $$ that maximizes the SNR of the PIVS$$ {\mathrm{PI}}_{\mathrm{VS}} $$ measurement.

SUBMITTER: Chen C 

PROVIDER: S-EPMC11782735 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature