Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults.

ABSTRACT:

Introduction

As no standard case definitions for respiratory syncytial virus-associated lower respiratory tract disease (RSV-LRTD) in adults are available, this study analyzed definitions for severe RSV-LRTD from previously published data in hospital and community cohorts of adults with RSV-associated symptoms.

Methods

The frequency, sensitivity, and specificity of acute respiratory disease symptoms among hospitalized and community cohorts of adults with RSV were analyzed. RSV-LRTD signs/symptoms assessed included shortness of breath (dyspnea), cough and/or fever, wheezing/rales/rhonchi (abnormal lung sounds by auscultation), sputum production, tachypnea, hypoxemia, and pleuritic chest pain.

Results

Dyspnea and tachypnea provided the best differentiation between hospi

SUBMITTER: Panozzo CA 

PROVIDER: S-EPMC11782790 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature