Lipid mediators in post-mortem brain samples from patients with Alzheimer's disease: A systematic review.

ABSTRACT: A proposed contributor to Alzheimer's disease (AD) pathology is the induction of neuroinflammation due to tau and beta-amyloid protein accumulation causing neuronal injury and dysfunction. Dysregulation of lipid mediators derived from polyunsaturated fatty acids may contribute to this inflammatory response in the brain of patients with AD, yet the literature has not yet been systematically reviewed. A systematic search was conducted in Medline, Embase and PsychINFO for articles published up to April 22, 2024. Papers were included if they measured levels of lipid mediators and/or enzymes involved in their production in post-mortem brain samples from patients with AD and control without neurological disease. A total of 50 relevant studies were identified. Despite heterogeneity in the

SUBMITTER: Tyrrell AD 

PROVIDER: S-EPMC11782888 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature