Corticomotor pathway function and recovery after stroke: a look back and a way forward.

ABSTRACT: Stroke is a leading cause of adult disability that results in motor deficits and reduced independence. Regaining independence relies on motor recovery, particularly regaining function of the hand and arm. This review presents evidence from human studies that have used transcranial magnetic stimulation (TMS) to identify neurophysiological mechanisms underlying upper limb motor recovery early after stroke. TMS studies undertaken at the subacute stage after stroke have identified several neurophysiological factors that can drive motor impairment, including membrane excitability, the recruitment of corticomotor neurons, and glutamatergic and GABAergic neurotransmission. However, the inherent variability and subsequent poor reliability of measures derived from motor evoked potentials (MEPs) lim

SUBMITTER: Shanks MJ 

PROVIDER: S-EPMC11782909 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature