Optimization of Mucoadhesive Oral Films Containing Olive Leaf Extract and Microencapsulated Thyme Essential Oil With Potential Antimicrobial Activity.

ABSTRACT: In this study, developing mucoadhesive oral films with optimized olive leaf extract (OLE) and microencapsulated thyme essential oil (TEO) contents was aimed to create a novel oral delivery system with desirable film properties as well as enhanced bioactivities. For this, TEO-containing sodium alginate/okra gum microcapsules were first fabricated at optimized electrospray conditions, where optimization was performed for three parameters, which are the flow rate of the emulsion solution, the potential difference, and the distance between the nozzle of the sample container and the collector plate, through three-level centered Box-Behnken design. Prior to the inclusion of the OLE in custom-designed mucoadhesive films, polymeric components of the films were also optimized through a separate mul

SUBMITTER: Goktas K 

PROVIDER: S-EPMC11782971 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature