Design, synthesis, antimicrobial activity, stability, and mechanism of action of bioresorbable ceragenins.

ABSTRACT: Device-related infections (DRIs) from bacterial/fungal biofilms that form on surfaces are a major cause of death in first-world countries. DRIs and the increasing prevalence of antibiotic resistant strains require development of new antimicrobials for improved antimicrobial prophylaxis. New antimicrobial prophylaxis practices necessitate novel agents to combat a broad spectrum of both fungi and bacteria, to be less toxic to patients, and to be locally administrable to prevent perturbations to a patient's microbiome. A class of antimicrobials that we have previously developed to fit these criteria is ceragenins. Here we describe the design, synthesis, and characterization of a new series of ceragenins that is composed of and degrades into endogenous compounds: cholic acid, B alanine, and gl

SUBMITTER: Gubler S 

PROVIDER: S-EPMC11782991 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature