Crosslinker-free <i>in situ</i> hydrogel induces self-aggregation of human dental pulp stem cells with enhanced antibacterial activity.

ABSTRACT: Recently, injectable hydrogels have garnered significant attention in tissue engineering due to their controlled flowability, strong plasticity, adaptability, and good biocompatibility. However, research on readily injectable in situ-forming hydrogels capable of forming functional three-dimensional (3D) tissue condensations remains limited. This study explores the development and evaluation of a carboxymethyl chitosan (CMCTS)/oxidized hyaluronic acid (oHA) hydrogel incorporated with silver sulfadiazine (AgSD) for tissue engineering applications with inherent antibacterial activity. Through physicochemical analysis, the optimal formulation of CMCTS/oHA hydrogels was established. The hydrogel demonstrated excellent injectability, enabling minimally invasive in situ delivery.

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC11783010 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature