Default mode network-basal ganglia network connectivity predicts the transition to postherpetic neuralgia.

ABSTRACT:

Background

Neuroimaging studies have revealed aberrant network functional connectivity in postherpetic neuralgia (PHN) patients. However, there is a lack of knowledge regarding the relationship between the brain network connectivity during the acute period and disease prognosis.

Objective

The purpose of this study was to detect characteristic network connectivity in the process of herpes zoster (HZ) pain chronification and to identify whether abnormal network connectivity in the acute period can predict the outcome of patients with HZ.

Methods

In this cross-sectional study, 31 patients with PHN, 33 with recuperation from herpes zoster (RHZ), and 28 with acute herpes zoster (AHZ) were recruited and underwent resting-state functional magnetic resonance imaging (fMRI). W

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11783054 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature